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Rosacea is a common [link widoczny dla zalogowanych] inflammatory skin disease that affects over 14 million Americans. [link widoczny dla zalogowanych] Rosacea causes redness and pimples on facial skin which can be quite agonizing. Although Rosacea is a harmless skin condition, it has a high impact on quality of life.
Causes And Risk Factors Of Rosacea
The cause of rosacea is [link widoczny dla zalogowanych] not known. Studies indicate a [link widoczny dla zalogowanych] genetic component, but a rosacea gene has not been identified.
Recent studies suggest that an altered innate immune response and dysregulation of the neurovascular system are involved in rosacea.
Various abnormal activities are observed in rosacea:
-- Dilated blood and lymphatic vessels
-- Increased blood flow
-- Enhanced blood vessel growth (angiogenesis)
-- Buildup of specialized immune and inflammatory cells
-- Activation of skin fibroblasts and enhanced tissue fibrosis
-- Decline of [link widoczny dla zalogowanych] keratinocyte-derived proteinases (important enzymes in the desquamation process and orderly regulation of the skin's barrier function)
-- Reduction of antioxidants that made inside the body
-- Augmented immune and inflammatory responses
A number of factors can aggravate above-mentioned abnormal activities. Some of these factors include:
-- Hot foods and beverages
-- Alcohol
-- Sunlight
-- Stress, anger or embarrassment
-- Vigorous exercise
-- Hot baths, saunas
-- Corticosteroids
-- Drugs that affects blood vessels, e.g., cardiovascular medications
Rosacea Symptoms
-- Redness of the face
-- Blushing or flushing easily
-- Spider-like blood vessels
-- Red nose
-- Acne-like skin sores that may [link widoczny dla zalogowanych] ooze or crust
-- Burning or stinging feeling in the face
-- Irritated, red, watery eyes
Rosacea Treatments
There are many treatment options available for rosacea, but there is no known cure for rosacea. The mainstay therapy for rosacea remains oral and topical antibiotics. However long-term use of antibiotics can cause antibiotic resistance. The most validated topical therapies include metronidazole, azelaic acid, and sodium sulfacetamide-sulfur. Other topical treatments, such as calcineurin inhibitors, benzoyl peroxide, clindamycin, retinoids, topical corticosteroids, and permethrin have demonstrated varying degrees of success.
Many rosacea sufferers find standard therapies unsatisfactory or even exacerbating. Due to the inconsistent results of drugs, rosacea patients are increasingly attracted to alternative treatments using natural products to ease inflammation and alleviate rosacea.
Stop The Suffering From Rosacea With Anti-inflammatory Remedies
Because inflammation initiates, propagates, and exacerbates rosacea symptoms, cooling inflammation can mitigate the suffering from rosacea.
Based on scientific literature, the following natural ingredients have shown therapeutic effects in treating inflammatory skin conditions including rosacea.
Licorice Extract
Licorice plants have been long used in alternative medicine for the treatment of a variety of inflammatory conditions. The main components of the licorice extract include triterpene saponins, flavonoids, and isoflavonoids.
Studies have shown that Licorice have anti-irritant and anti-inflammatory properties. It suppresses oxidative stress (i.e., reduces superoxide anion production and cyclooxygenase activity), reduces inflammation, promotes mucous secretion, soothes irritation, and stimulates adrenal gland activity.
In addition, licorice appears to exert immunomodulatory, antiviral and antimicrobial activity. Topical preparations have been shown to significantly decrease scores of [link widoczny dla zalogowanych] erythema, edema, itching, and improve the quality of life.
Green Tea Extract
Green tea is one of the most extensively studied antioxidants. Green tea extract contains potent antioxidant, anti-inflammatory, and anticarcinogenic polyphenols known as catechins. These polyphenols are active in initiating cellular and molecular responses in the top layers of the skin (i.e., epidermis).
Green tea extract possesses [link widoczny dla zalogowanych] antioxidant properties by eliminating reactive oxygen species and inhibiting various enzymes that are involved in oxidative stress (i.e., nitric oxide synthetase, lipoxygenase, cyclooxygenase, and lipid peroxidase). Green tea extract exerts anti-inflammatory activity via [link widoczny dla zalogowanych] inhibition of the infiltration of inflammatory cells and decrease of inflammatory mediators. Finally, green tea extract is anti-carcinogenic by preventing carcinogen-DNA binding and subsequent tumorigenesis.
Besides the anti-inflammatory and antioxidant properties, which make green tea extract useful in the treatment of rosacea, the protection it affords from UV light makes it particularly useful as rosacea is often triggered by light exposure.
Topical applications of green tea extract have been shown to decrease UV-induced erythema and to reduce DNA damage. Green tea extract may also directly improve the signs of rosacea by reducing the number and appearance of small dilated blood vessels (telangiectasias) and minimize the disruption of the skin barrier.
Scute Extract
Scute has been used for centuries in traditional medicine to treat inflammation, allergies, infections and skin disorders.
Studies have shown that Scute possesses anti-inflammatory, antibacterial, antifungal, anti-viral, anti-allergic, and anti-tumor properties. It is one of the most widely used in Chinese herbal medicine.
The bioactivity of scute is due to the [link widoczny dla zalogowanych] radical scavenging activities of the flavone components. More than 60 flavonoids have been identified in the root of scute. Scute extracts produce potent anti-inflammatory activities through inhibiting a broad panel of inflammatory mediators.
Aloe Extract
Aloe extract is known to have anti-inflammatory, analgesic, antipruritic, and wound-healing properties. Its active components include salicylic acid (anti-inflammatory via thromboxane and prostaglandin inhibition), magnesium lactate (antipruritic via histidine decarboxylase inhibition), and gel polysaccharides (anti-inflammatory via immunomodulation).
Aloe has been studied with success in the treatment of burning, itching, and scarring associated with inflammatory skin conditions. Studies also showed decreases in vessel dilation and vascular permeability, key features of rosacea.
Aloe has shown promising results in treating various skin infections such as boils, cysts, ringworm, athlete's foot, and jock itch. Its renowned healing, moisturizing, and softening properties are widely used to soothe the skin and help heal cuts, burns and insect bites.
Chamomile Extract
Chamomile contains active components of terpenoids and flavonoids that inhibit enzymes (cyclooxygenase and lipoxygenase) involved in oxidation process. These compounds also regulate the immune cell activation and histamine release during allergic reaction. Topical applications have been shown [link widoczny dla zalogowanych] to be beneficial in skin inflammation and skin irritation.
Reishi Mushroom Extract
Extracts from mushrooms, such as shiitake and reishi, contain several compounds (i.e., polysaccharides, triterpenes, proteins, lipids, phenols, and cerebrosides) that have meaninful anti-inflammatory and antioxidant properties. These compounds inhibit lipid oxidation, matrix degradation, and production of inflammatory cytokines.
To learn more about inflammatory skin conditions and how to cool inflammation with natural anti-inflammatory remedies, follow blog series "Nature's Best Anti-inflammatory Herbs" and "Natural Cures For Chronic Inflammatory Conditions".
References:
1. Rosacea: The cytokine and chemokine network. Gerber PA. Buhren BA. et al. Journal of Investigative Dermatology. Symposium Proceedings. 15(1):40-7, 2011
2. Epidermal proteases in the pathogenesis of rosacea. Meyer-Hoffert U. Schroder JM. Journal of Investigative Dermatology. Symposium Proceedings. 15(1):16-23, 2011
3. Inflammation in rosacea and acne: Implications for patient care. Fleischer AB Jr. Journal of Drugs in Dermatology: JDD. 10(6):614-20, 2011
4. Botanicals and anti-inflammatories: natural ingredients for rosacea. Emer J. et al. Seminars in Cutaneous Medicine & Surgery. 30(3):148-55, 2011
5. Skin photo protection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Nichols JA, Katiyar SK. Arch Dermatol Res (2010) 302:71-83
6. Targeting of histamine producing cells by EGCG: a green dart against inflammation? Melgarejo E, et al. J Physiol Biochem (2010) 66:265-270
Dr Yi Shi, founder of Innovative Drug Discovery and 3rSkinCare.com is well recognized in inflammatory disease research. Dr Shi has accomplished numerous research projects and published [link widoczny dla zalogowanych] over 40 research articles in medical journals. For nearly a decade, Dr Shi has led collaborative efforts to develop natural anti-inflammatory products and establish 3R Skincare System for common skin conditions.
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